{
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  "Package": "ltRISK",
  "Title": "Estimate Lifetime and Age-Conditional Risk of Developing or\nDying from Cancer",
  "Version": "0.1.0",
  "Authors@R": "person(\"Qiong\", \"Chen\",\nemail = \"chenq08@126.com\",\nrole = c(\"aut\", \"cre\", \"cph\"),\ncomment = c(ORCID = \"0000-0003-2401-0046\"))",
  "Description": "Estimates lifetime and age-conditional risks of developing\nor dying from cancer using population-based cancer registry\ndata. Four established approaches for lifetime risk estimation\nare implemented: the DevCan method developed by the\nSurveillance, Epidemiology, and End Results (SEER) Program, the\nWun method, the Adjusted for Multiple Primary Cancers (AMP)\nmethod, and a cumulative risk approach with a predefined upper\nage limit. The package provides a unified interface through the\ncalc_ltr() function, which supports both gamma-based and\ndelta-method confidence intervals, as well as the piecewise\nmid-age group joinpoint (PMAJ) model for age-specific rate\nmodeling.",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
  "Language": "en-US",
  "Roxygen": "list(markdown = TRUE)",
  "LazyData": "true",
  "URL": "https://github.com/gigu003/ltRISK",
  "BugReports": "https://github.com/gigu003/ltRISK/issues",
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  "Repository": "https://gigu003.r-universe.dev",
  "Date/Publication": "2026-08-15 16:02:41 UTC",
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  "Packaged": {
    "Date": "2026-09-14 09:20:22 UTC",
    "User": "root"
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  "Author": "Qiong Chen [aut, cre, cph] (ORCID:\n<https://orcid.org/0000-0003-2401-0046>)",
  "Maintainer": "Qiong Chen <chenq08@126.com>",
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  "_created": "2026-09-14T09:20:22.000Z",
  "_published": "2026-09-14T09:32:02.521Z",
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    "author": "Qiong Chen <chenq08@126.com>",
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  "_owner": "gigu003",
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  "_updates": [
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      "week": "2026-31",
      "n": 2
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  "_devurl": "https://github.com/gigu003/ltrisk",
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  "_assets": [
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    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
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    "calc_ltr",
    "calc_ltr_df",
    "clear_ltr_cache",
    "cumulative",
    "devcan",
    "format_risk_ci",
    "get_risk",
    "ltr_cache_info",
    "pairwise_ztest",
    "pmaj",
    "trend_test",
    "wun",
    "ztest"
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      "name": "GCO_Today_2022",
      "title": "GCO_Today_2022",
      "object": "GCO_Today_2022",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
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      "fields": [
        "site_code",
        "icd10",
        "site_abbr",
        "ages",
        "cancer",
        "cancer_death",
        "death",
        "pys"
      ],
      "rows": 702,
      "table": true,
      "tojson": true
    },
    {
      "name": "seer_example_data",
      "title": "Example Cancer Data from SEER",
      "object": "seer_example_data",
      "class": [
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        "tbl",
        "data.frame"
      ],
      "fields": [
        "site",
        "period",
        "sex",
        "ages",
        "cancer",
        "death",
        "cancer_death",
        "pys"
      ],
      "rows": 80,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "amp",
      "title": "Compute probabilities used for estimation of lifetime risk",
      "topics": [
        "amp"
      ]
    },
    {
      "page": "calc_ltr",
      "title": "Estimate disease risk and its confidence interval",
      "topics": [
        "calc_ltr"
      ]
    },
    {
      "page": "calc_ltr_df",
      "title": "Estimate disease risk from a data frame",
      "topics": [
        "calc_ltr_df"
      ]
    },
    {
      "page": "clear_ltr_cache",
      "title": "Manage ltRISK in-memory caches",
      "topics": [
        "clear_ltr_cache",
        "ltr_cache_info"
      ]
    },
    {
      "page": "cumulative",
      "title": "Calculate cumulative rate and risk.",
      "topics": [
        "cumulative"
      ]
    },
    {
      "page": "devcan",
      "title": "Compute probabilities used for estimation of lifetime risk",
      "topics": [
        "devcan"
      ]
    },
    {
      "page": "format_risk_ci",
      "title": "Format risk estimates with 95% confidence intervals",
      "topics": [
        "format_risk_ci"
      ]
    },
    {
      "page": "GCO_Today_2022",
      "title": "GCO_Today_2022",
      "topics": [
        "GCO_Today_2022"
      ]
    },
    {
      "page": "get_risk",
      "title": "Calculate the risk value for a specific age range",
      "topics": [
        "get_risk",
        "get_risk.amp",
        "get_risk.cumu",
        "get_risk.devcan",
        "get_risk.wun"
      ]
    },
    {
      "page": "pairwise_ztest",
      "title": "Pairwise Z tests for risk differences among groups",
      "topics": [
        "pairwise_ztest"
      ]
    },
    {
      "page": "pmaj",
      "title": "Smooth a Single Rate Using Piecewise Mid-Age Group Joinpoint (PMAJ) Method",
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        "pmaj"
      ]
    },
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      ]
    },
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      "title": "Test linear trend in risk across ordered groups",
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      ]
    },
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      "title": "Compute probabilities used for estimation of lifetime risk",
      "topics": [
        "wun"
      ]
    },
    {
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      "title": "Test the difference in risk between two groups",
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        "ztest.data.frame"
      ]
    }
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  "_pkglogo": "https://github.com/gigu003/ltRISK/raw/HEAD/man/figures/logo.png",
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    "rlang"
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    {
      "source": "use-ltRISK.Rmd",
      "filename": "use-ltRISK.html",
      "title": "Estimate lifetime risk of developing or dying from cancer using ltRISK",
      "author": "Qiong Chen",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Installation",
        "Methods",
        "Overview of available approaches",
        "Which method should I use?",
        "Literature and implementation status",
        "Using ltRISK",
        "Load the package",
        "Data preparation",
        "Example datasets",
        "Data-frame and tidyverse-style interface",
        "Rate modeling and confidence intervals",
        "PMAJ rate modeling",
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        "Gamma confidence intervals",
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        "Method 2: Wun method",
        "Method 3: AMP method",
        "Method 4: Traditional cumulative risk",
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        "References"
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      "created": "2026-08-02 09:36:09",
      "modified": "2026-08-15 16:02:41",
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